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If you could create your agent using Java you can use JDBC to handle the connectivity to your MySQL, SQLServer or DB2 RDBMS. I do it all the time and it works great and has been running for years.
Also, you could check into LEI (Lotus Enterprise Integration).
Feedback response number WEBB9TUJLB created by ~Umberto Xanluchekettu on 02/18/2015